Knockout of vascular early response gene worsens chronic stroke outcomes in neonatal mice

Changes in vascular reactivity of the coronary artery and thoracic aorta in the delta sarcoglycan null mutant mice

Introduction: Mutations in the delta sarcoglycan gene (d-SG) cause limb-girdle muscular dystrophy type 2F with structural and functional alterations in cardiac, smooth and skeletal muscle. The objective of the present study was to improve information about changes in vascular reactivity of the thoracic aorta and the coronary artery in the perfused heart of the d-SG-null mutant mouse model. ...

Impact of Extension Splint on Upper Extremity Motor Components and Function in Chronic Stroke Patients

Objectives: Spasticity and contracture in flexor muscles of the wrist may occur after stroke, especially in which early recovery did not appear. Splints are prescribed to reduce spasticity and to prevent contracture after stroke. Although there is a few research in this field. The aim of this study was to examine the impact of the Extension splint on function, spasticity, and range of motion of...

Effects of capsaicin in low doses and high doses on the small intestine motor response in wild-type and TRPV1 knockout mice

NFATc3 is required for chronic hypoxia-induced pulmonary hypertension in adult and neonatal mice.

Pulmonary hypertension occurs with prolonged exposure to chronic hypoxia in both adults and neonates. The Ca(2+)-dependent transcription factor, nuclear factor of activated T cells isoform c3 (NFATc3), has been implicated in chronic hypoxia-induced pulmonary arterial remodeling in adult mice. Therefore, we hypothesized that NFATc3 is required for chronic hypoxia-induced pulmonary hypertension i...

Generation of global Spata19 knockout mouse using CRISPR/Cas9 nickase technology

Introduction: SPATA19 gene is expressed in developmental stages of testis and some organs, but so far its function has only been examined in the testis. In this study, we provided an effective pathway for the generation of these mice using new CRISPR / Cas9 nickase method while generating Spata19 knockout mice for future studies in other organs. Materials and Methods: CRISPR / Cas9 nickase plas...